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Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia

K A Gleason; et al
3 de junho de 2013
Clinical studies report associations between cannabis use during adolescence and later onset of schizophrenia. We examined the causal relationship between developmental cannabinoid administration and long-term behavioral and molecular alterations in mice. Mice were administered either...


Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism

R A Clarke; S Lee;V Eapen
3 de junho de 2013
Tourette syndrome (TS) is a highly heritable neuropsychiatric disorder characterised by motor and vocal tics. Despite decades of research, the aetiology of TS has remained elusive. Recent successes in gene discovery backed by rapidly advancing genomic technologies have given us new insights into the...


Early childhood temperament predicts substance use in young adults

A Lahat; et al
3 de junho de 2013
Behavioral inhibition (BI) is an important early childhood marker of risk for later psychiatric problems. The current 20-year prospective, longitudinal study focused on individual differences in this early temperament and adolescent brain function...


Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

S. Rose; et al
3 de junho de 2012
Despite increasing evidence of oxidative stress in the pathophysiology of autism, most studies have not evaluated biomarkers within specific brain regions, and the functional consequences of oxidative stress remain relatively understudied...


Circadian profiles in young people during the early stages of affective disorder

S L Naismith; et al
3 de junho de 2013
Although disturbances of the circadian system are strongly linked to affective disorders, no known studies have examined melatonin profiles in young people in early stages of illness. In this study, 44 patients with an affective disorder underwent clinical and neuropsychological assessments...


Use of machine learning to shorten observation-based screening and diagnosis of autism

D P Wall; et al
3 de junho de 2013
The Autism Diagnostic Observation Schedule-Generic (ADOS) is one of the most widely used instruments for behavioral evaluation of autism spectrum disorders. It is composed of four modules, each tailored for a specific group of individuals based on their language and developmental level...


A novel blood-based biomarker for detection of autism spectrum disorders

N. Momeni; et al
3 de junho de 2013
Autism spectrum disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to the development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used...


Reliability and convergent validity of the Childhood Anxiety Sensitivity Index in children and adolescents

Luciano Isolan; et al
5 de maio de 2013
Anxiety sensitivity (AS) refers to the tendency to fear anxiety-related sensations and is thought to arise from beliefs about their harmful physical, cognitive, or social consequences...


Perfil clínico e sociodemográfico de adolescentes que permaneceram e não permaneceram no tratamento em um CAPSad de Cuiabá/MT

Nayara Bueno de Araujo; Samira Reschetti Marcon; Naiara Gajo Silva; José Roberto Temponi de Oliveira
5 de maio de 2013
A atenção à saúde mental no Brasil, nos últimos 20 anos, passou por um redirecionamento de modelo de assistência centrado no hospital psiquiátrico para um modelo comunitário, caracterizado pela construção de uma rede de serviços extra-hospitalar articulada a dispositivos de atenção à saúde como os...


The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder

Cristian Patrick Zeni; et al
5 de maio de 2013
Children and adolescents with bipolar disorder [juvenile bipolar disorder (JBD)] present disabling affective and behavioral dysregulation, aggressiveness, and irritability...


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